abstract：:To elucidate the role of major chemotactic factors, cytokine-induced neutrophil chemoattractant (CINC), leukotriene B4 (LTB4) and C5a in lipopolysaccharide (LPS)-induced acute lung injury in rat, we employed three reagents: anti-CINC-1 antibody, an LTB4 receptor antagonist (ONO-4057) and an anti-complementary agent (K...

journal_title：Inflammation

authors： Yamasawa H,Ishii Y,Kitamura S

更新日期：1999-06-01 00:00:00

abstract：:Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...

journal_title：Inflammation

authors： Kankuri E,Asmawi MZ,Korpela R,Vapaatalo H,Moilanen E

更新日期：1999-04-01 00:00:00

abstract：:Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...

journal_title：Inflammation

authors： Okayama N,Coe L,Itoh M,Alexander JS

更新日期：1999-02-01 00:00:00

abstract：:The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...

journal_title：Inflammation

authors： Mahomed AG,Theron AJ,Anderson R,Feldman C

更新日期：1998-12-01 00:00:00

abstract：:Dialysate and serum levels of granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and leukemia inhibitory factor (LIF) were analyzed in patients with continuous ambulatory peritoneal dialysis (CAPD). Samples from the peritoneal effluent and from serum were obtained ...

journal_title：Inflammation

authors： Brauner A,Hylander B,Lu Y

更新日期：1998-08-01 00:00:00

abstract：:The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...

journal_title：Inflammation

authors： Verdegaal EM,Zegveld ST,Beekhuizen H,Bakker W,van Furth R

更新日期：1998-04-01 00:00:00

abstract：:The phenotypic alterations between blood monocytes from 11 patients with end-stage renal disease, who had been on peritoneal dialysis for less than one week, and blood monocytes from 10 healthy controls, were analyzed. In addition, peritoneal macrophages in the dialysate effluent were enclosed. Analysis of functional ...

journal_title：Inflammation

authors： Brauner A,Lu Y,Halldén G,Hylander B,Lundahl J

更新日期：1998-02-01 00:00:00

abstract：:Heat shock (HS) proteins (HSP) are a family of molecular chaperones induced by environmental stresses such as oxidative injury, and contribute to protection from and adaptation to cellular stress. We investigated in human monocytes the expression and subcellular distribution of hsp70 and hsc70 after HS and inflammatio...

journal_title：Inflammation

authors： Mariéthoz E,Jacquier-Sarlin MR,Multhoff G,Healy AM,Tacchini-Cottier F,Polla BS

更新日期：1997-12-01 00:00:00

abstract：:Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellul...

journal_title：Inflammation

authors： Movitz C,Sjölin C,Dahlgren C

更新日期：1997-10-01 00:00:00

abstract：:T cells adhere to human dermal fibroblasts (HDF). This cellular interaction leads to a pronounced secretion of the proinflammatory cytokines IL-6 and IL-8 via a juxtacrine stimulation induced by HDF-associated IL-1. Upon stimulation, fibroblasts express various surface proteins such as MCH-I molecules, which may inter...

journal_title：Inflammation

authors： Spörri B,Bickel M,Limat A,Waelti ER,Hunziker T,Wiesmann UN

更新日期：1997-08-01 00:00:00

abstract：:An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...

journal_title：Inflammation

authors： Morris PE,Glass J,Cross R,Cohen DA

更新日期：1997-06-01 00:00:00

abstract：:Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as t...

journal_title：Inflammation

authors： Lefkowitz DL,Lincoln JA,Howard KR,Stuart R,Lefkowitz SS,Allen RC

更新日期：1997-04-01 00:00:00

abstract：:In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...

journal_title：Inflammation

authors： Haker E,Theodorsson E,Lundeberg T

更新日期：1997-02-01 00:00:00

abstract：:NO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) was assessed by means of nitrite measurement in pleural exudate from 0.5 to 24 h. NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transie...

journal_title：Inflammation

authors： Regnault C,Roch-Arveiller M,Florentin I,Giroud JP,Postaire E,Delaforge M

更新日期：1996-12-01 00:00:00

abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...

journal_title：Inflammation

authors： Kivistö K,Punnonen K,Toppari J,Leino L

更新日期：1996-10-01 00:00:00

abstract：:Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...

journal_title：Inflammation

authors： Li J,Gyorffy S,Lee S,Kwok CS

更新日期：1996-08-01 00:00:00

abstract：:Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...

journal_title：Inflammation

authors： Pouliot N,Maghni K,Sirois P,Rola-Pleszczynski M

更新日期：1996-06-01 00:00:00

abstract：:Nitric Oxide (NO) is a reactive metabolite produced by stimulated macrophages, and it has been demonstrated to exert cytotoxic actions on a number of microbes, parasites, and tumor cells. In addition, NO has been reported to have an autotoxic effect on murine macrophages, its site of synthesis. We have investigated th...

journal_title：Inflammation

authors： Bochsler PN,Mason GL,Olchowy TW,Yang Z

更新日期：1996-04-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of f...

journal_title：Inflammation

authors： Ishizuka T,Hirata I,Adachi M,Kurimoto F,Hisada T,Dobashi K,Mori M

更新日期：1995-12-01 00:00:00

abstract：:The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. IL-1 beta increased levels of mRNA for COX-2 whereas the COX-1 mRNA level was unaffected. The increased CO...

journal_title：Inflammation

authors： Yucel-Lindberg T,Ahola H,Nilsson S,Carlstedt-Duke J,Modéer T

更新日期：1995-10-01 00:00:00

abstract：:After severe burns, a wound revision is often done to remove devitalized tissue and minimize bacterial growth. After such revision, the patient may show signs of sepsis. In a group of burned patients we found a transient endotoxemia, and a subsequent leukocyte activation, monitored as increased expression of the beta ...

journal_title：Inflammation

authors： Ljunghusen O,Berg S,Hed J,Lundahl J,Nettelblad H,Sjögren F,Stendahl O

更新日期：1995-08-01 00:00:00

abstract：:Previous studies indicate that aspirin can promote neutrophil (PMN) adhesion to endothelial cells and neutrophil-mediated endothelial cell detachment. The objectives of the present study were to determine whether PMN adhesion is a prerequisite for aspirin-induced, PMN-mediated endothelial cell detachment and whether n...

journal_title：Inflammation

authors： Yoshida N,Cepinskas G,Granger DN,Anderson DC,Wolf RE,Kvietys PR

更新日期：1995-06-01 00:00:00

abstract：:Chemical alteration of the glucocorticoid, methylprednisolone, has led to the introduction of a new class of compounds called the 21-aminosteroids (21-ASs). The purpose of this study was to investigate the effect of the 21-AS, U74389G, on silica-induced acute lung injury. Male Fischer 344 rats were treated intraperito...

journal_title：Inflammation

authors： Antonini JM,van Dyke K,DiMatteo M,Reasor MJ

更新日期：1995-02-01 00:00:00

abstract：:A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...

journal_title：Inflammation

authors： Hu DE,Fan TP

更新日期：1995-02-01 00:00:00

abstract：:Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...

journal_title：Inflammation

authors： Bhattacharyya SN,Ashbaugh P,Kaufman B,Manna B

更新日期：1994-12-01 00:00:00

abstract：:Gossypol is present in antiinflammatory poultices made from the medicinal tree Thespesia populnea. Isolated human neutrophils exposed to 3-20 microM gossypol for 15-90 min were assayed in vitro for superoxide production and surface expression of Mac-1 (CD11b/CD18). Gossypol increased superoxide production in a time- a...

journal_title：Inflammation

authors： Benhaim P,Mathes SJ,Hunt TK,Scheuenstuhl H,Benz CC

更新日期：1994-10-01 00:00:00

abstract：:This study examined the hypothesis that tumor cells metastatic to the pleura secrete a soluble factor(s) that directly increases endothelial cell permeability. Nitrocellulose filters were endothelialized with bovine pulmonary artery endothelial cells and exposed to conditioned media from either human lung adenocarcino...

journal_title：Inflammation

authors： Payne DK,Fuseler JW,Owens MW

更新日期：1994-08-01 00:00:00

abstract：:The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...

journal_title：Inflammation

authors： Carreras MC,Catz SD,Pargament GA,Del Bosco CG,Poderoso JJ

更新日期：1994-04-01 00:00:00

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Crohn's disease is an idiopathic, chronic inflammation of the gastrointestinal tract that causes narrowing and stricturing of primarily the small and large intestine. Although the mechanism(s) by which chronic inflammation promotes stricture formation remain to be defined, it does appear to be associated histologicall...

journal_title：Inflammation

authors： Owens MW,Grisham MB

更新日期：1993-08-01 00:00:00

abstract：:In this study, we assessed the underlying mechanisms by which proteinases released from activated neutrophils mediate fibronectin degradation. Purified human neutrophils (1 x 10(6)) were incubated for 1 hr with 1 microM PMA in the absence or presence of different proteinase inhibitors in 96-well microtiter plates that...

journal_title：Inflammation

authors： Kubes P,Smith R,Grisham MD,Granger DN

更新日期：1993-06-01 00:00:00

abstract：:Extracellular phospholipase A2 (PLA2) activity was detected in exudate from rat carrageenan-induced pleurisy using [3H]oleic acid-labeled Escherichia coli as substrate. Both exudate volume and PLA2 activity increased up to 24 h after carrageenin injection. Specific absorption of this activity by anti-group II PLA2 (PL...

journal_title：Inflammation

authors： Tanaka K,Kato T,Matsumoto K,Yoshida T

更新日期：1993-04-01 00:00:00

abstract：:Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...

journal_title：Inflammation

authors： Baumann MH,Heinrich K,Sahn SA,Strange C

更新日期：1993-02-01 00:00:00

abstract：:Thermal injury in rats leads to an impairment of polymorphonuclear leukocyte (PMN) functions, particularly oxidative metabolism and phosphoinositide turnover. As prostaglandin E2, which has immunosuppressive properties, is released in high levels after burn trauma, we investigated the in vitro and in vivo effects of a...

journal_title：Inflammation

authors： Tissot M,Roch-Arveiller M,Fontagne J,Giroud JP

更新日期：1992-12-01 00:00:00

abstract：:Recombinant human tumor necrosis factor-alpha (rTNF) stimulated increased generation of superoxide anion (O2-) by human neutrophils in a concentration-dependent fashion. Preincubation of human neutrophils with rTNF (2.2-2200 units/ml) for 10 min enhanced the subsequent generation of O2- in response to C5a and f-Met-Le...

journal_title：Inflammation

authors： Bajaj MS,Kew RR,Webster RO,Hyers TM

更新日期：1992-06-01 00:00:00

abstract：:Platelets activated with physiological agonists, such as thrombin, ADP, or collagen, released products able to modulate neutrophil functions. In particular, platelet supernatant contained an inhibitor of superoxide anion generation induced by phorbol ester and a chemotactic factor for human neutrophils. The proteolyti...

journal_title：Inflammation

authors： Spisani S,Giuliani AL,Cavalletti T,Zaccarini M,Milani L,Gavioli R,Traniello S

更新日期：1992-04-01 00:00:00

abstract：:In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...

journal_title：Inflammation

authors： Hirasawa N,Watanabe M,Mue S,Watanabe K,Tsurufuji S,Ohuchi K

更新日期：1992-04-01 00:00:00

abstract：:The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...

journal_title：Inflammation

authors： Brown DM,Brown GM,Macnee W,Donaldson K

更新日期：1992-02-01 00:00:00

abstract：:Colchicine and methotrexate are commonly used in the treatment of gout and rheumatoid arthritis, respectively; however the mechanism(s) of action of these drugs remain(s) unknown. The objective of this study was to determine whether colchicine and methotrexate can modify the adhesion and emigration of leukocytes in po...

journal_title：Inflammation

authors： Asako H,Kubes P,Baethge BA,Wolf RE,Granger DN

更新日期：1992-02-01 00:00:00